Production in guinea pigs of antibodies to cross-reactive antigenic determinants of human enteroviruses.

Insulin Antibody Variations in Rabbits and Guinea Pigs and Multiple Antigenic Determinants on Insulin

1. A method is presented for measuring the degree to which insulin antibodies in one antiserum react with an insoluble insulin complex saturated with antibodies from a different antiserum. 2. Many rabbits produce antibodies which bind to portions of the insulin molecule to which antibodies from guinea pigs or other rabbits cannot bind. 3. Occasional guinea pigs produce antibodies which bind to ...

Genetic Control of Combining Sites of Insulin Antibodies Produced by Guinea Pigs*,

Several reports (1-3) where large molecular weight natural-occurring antigens and markedly heterogeneous antigenic material were used have demonstrated a statistically significant relationship of genetic factors to the immune response. More recently Levine, Ojeda, and Benacerraf (4, 5) have been able to demonstrate a genetic control of the immune response of guinea pigs immunized with hapten-po...

Evaluation of Seroconversion in Guinea Pigs Following Inoculation of New Formulations of Rubella Vaccine

Background and Aims: Rubella is a contagious viral disease mostly with mild clinical symptoms and often remains undiagnosed. Rubella infection may adversely affect pregnancy, especially in the first trimester and this mother to child transmission can cause congenital rubella and may be lead to permanent disability and mortality in children. Effective rubella vaccine should be prepared using sui...

A comparison of virulence of intraperitoneal infection of Burkholderia mallei strains in guinea-pigs

Male guinea pigs show high susceptibility to Burkholderia mallei and have been used as animal models in glanders studies. The purpose of our study was to elucidate glanders comparative pathogenesis in guinea pigs. We present here the histological changes and bacterial isolation that develop over time in guinea pigs inoculated intraperitoneally (IP) with two strain of B. mallei. Ten male guinea ...

Studies on the rapid production of Foot and Mouth disease hypenmmune antisera in guinea pigs